The reaction of substituted aromatic aldehydes with ethylacetoacetate in presence of ammonia solution yielded diethyl-2,6-dimethyl-4-(substitutedphenyl)1,4-dihydropyridine3,5-dicarboxylate (1), which on treatment with hydrazine hydrate produced 2,6-dimethyl-4-(substituted phenyl)-1,4-dihydropyridine-3,5-dicarbohydrazide (2), cyclization with substituted benzoic acids in presence of phosphorous oxychloride produced 2,6-dimethyl-4-(substitutedphenyl)3,5-[bis-(5’-substitutephenyl1’,3’,4’-oxadiazolo)] 1, 4dihydropyridine (3a-l). Purity was checked by TLC and the chemical structures of synthesized compounds were elucidated by their IR, 1H NMR analysis data. The synthesized compounds were screened for Anti-inflammatory activity.
Loading....